Oxytocin is a neuropeptide with known anxiolytic properties. However, little is known about the role of OT in avoidance behaviour, a hallmark of anxiety disorders. Using a platform-mediated avoidance model, we investigated the impact of LIT-001 non-peptide OT agonist on the expression and extinction of conditioned avoidance behaviours in female rats. Female Sprague Dawley rats underwent 10-days of training to learn to avoid a tone-signalled footshock (75dB, 4kHz, 28s tone, 0.4mA 2s shock, 9 tones/day) by stepping on a non-conductive platform. On day 11, rats received either a single dose of LIT-001 (10mg/kg i.p, n=8), or vehicle (i.p, n=8) 1 hour prior to an extinction protocol (9 tones presented without footshock). Analysis revealed no significant difference between LIT-001- and vehicle-treated rats in measures of time with food, time on platform, or time spent reaching off the platform during either tones or inter-tone periods. The following day, rats were exposed to a further 3 tone presentations without footshock. There was no significant difference between LIT-001- and vehicle-treated animals in time on platform or time with food during tone or inter-tone periods.  However, LIT-001-treated rats spent significantly less time reaching off the platform during inter-tone periods than vehicle-treated rats (p<0.0001).  These results suggest that while systemic administration of LIT-001 does not influence expression or extinction of conditioned avoidance, it may have subtle effects on the expression of metastability-like behaviours during motivational conflict.